Why the study?
Does ticlopidine prevent thrombotic obstruction in an experimental arterio-venous shunt model in rats?
Population
Wistar-Imamichi male rats with an experimental loop-shaped arterio-venous shunt installed between the right…
Comparison
Oral administration of ticlopidine… vs Vehicle alone given orally.
Design
Preclinical
Follow-up
4 hours
Authors
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Ticlopidine shows model-specific efficacy where aspirin and dipyridamole do not; hypothesis-generating for human shunt patency trials.
Does ticlopidine prevent thrombotic obstruction in an experimental arterio-venous shunt model in rats?
Ticlopidine effectively prevents thrombotic obstruction in a rat arterio-venous shunt model, unlike aspirin, likely because it does not inhibit vascular PGI2 generation.
Ashida et al. (1980) studied this question.
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