Population
Patients with chronic heart failure and controls without heart failure
Design
Case-control
Authors
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Functional vascular defects may contribute to HF without structural remodeling; hypothesis-generating for endothelin-targeted studies in larger cohorts.
Small-artery structure is not altered in chronic heart failure, but functional abnormalities such as impaired vasoconstriction to endothelin-1 and abnormal neuronal uptake are present.
Hillier et al. (1999) studied this question.
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