Why the study?
Do small resistance arteries from patients with congestive heart failure have impaired pharmacological reactivity compared to normal volunteers?
Population
Small resistance arteries from gluteal skin biopsy specimens of 6 patients with congestive heart failure and…
Comparison
Ex vivo exposure to vasoconstrictors and… vs Arteries from normal volunteers
Design
Case-control
Authors
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Impaired reactivity in resistance arteries may contribute to peripheral dysfunction in CHF; hypothesis-generating for endothelial and contractile mechanisms, should not yet change practice.
Do small resistance arteries from patients with congestive heart failure have impaired pharmacological reactivity compared to normal volunteers?
Skin resistance arteries in chronic congestive heart failure exhibit impaired contraction and endothelium-dependent vasodilatation, suggesting a role in peripheral vascular dysfunction.
Angus et al. (1993) studied this question.
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