Why the study?
Does breathing 30-50% N2O depress ventilatory responses to CO2 and hypoxia in normal volunteers?
Population
4 normal volunteers
Comparison
Breathing 30-50 per cent N2O with and without… vs Breathing without N2O
Design
Other
Authors
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May warrant caution with N2O in hypoxemic patients; leaves open effects in clinical disease states.
Does breathing 30-50% N2O depress ventilatory responses to CO2 and hypoxia in normal volunteers?
Nitrous oxide selectively depresses the ventilatory response to hypoxia, likely through peripheral chemoceptor depression.
Yacoub et al. (1976) studied this question.