July 1, 2003The Journal of ImmunologyOpen Access

Persistent Infection of Human Microvascular Endothelial Cells by Coxsackie B Viruses Induces Increased Expression of Adhesion Molecules

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Population

Human dermal microvascular endothelial cells and macrovascular human umbilical vein endothelial cells

Comparison

Infection with three Coxsackievirus B strains vs Uninfected HMEC-1 and HUVEC monolayers

Design

Preclinical

Follow-up

up to 3 months

Authors

MZMaria M. ZanoneUniversity of Turin EFEnrica FavaroUniversity of Turin PCPier Giulio ConaldiIstituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione

Discussion

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Implication

Endothelial activation by CVB may promote inflammation; leaves open relevance to human myocarditis or vasculitis.

Structured PICO

Population

Human dermal microvascular endothelial cells (HMEC-1) and macrovascular human umbilical vein endothelial cells (HUVEC)

Intervention

Infection with three Coxsackievirus B (CVB) strains

Comparator

Uninfected HMEC-1 and HUVEC monolayers

Outcome

Expression of adhesion molecules (ICAM-1, VCAM-1), production of proinflammatory cytokines (IL-6, IL-8, TNF-alpha), and mononuclear cell adhesionsurrogate

Persistent Coxsackievirus B infection of microvascular endothelial cells upregulates adhesion molecules and proinflammatory cytokines, potentially driving leukocyte recruitment during inflammatory immune responses.

Cite This Study

Zanone et al. (2003) studied this question.

synapsesocial.com/papers/6a90d84dfae915895c3607c5 https://doi.org/10.4049/jimmunol.171.1.438

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Persistent Infection of Human Microvascular Endothelial Cells by Coxsackie B Viruses Induces Increased Expression of Adhesion Molecules

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Persistent Infection of Human Microvascular Endothelial Cells by Coxsackie B Viruses Induces Increased Expression of Adhesion Molecules

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider