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March 9, 2021European Journal of Preventive CardiologyOpen Access

Heart failure and depression: a comparative analysis with different types of cancer

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Why the study?

Depression significantly impacts heart failure prognosis and quality of life, but comparative data on depression incidence between heart failure and common cancers are limited.

Does heart failure increase the incidence of depression and anxiety compared to common cancers in adult outpatients?

Population

96 772 HF, 21 261 breast, 16 478 prostate, and 29 479 digestive cancer outpatients in Germany

Comparison

Heart failure vs breast cancer vs prostate cancer vs cancer of the digestive organs

Design

Retrospective cohort study

Follow-up

Mean 4.6 to 5.0 years

Authors

SLSven H. LoosenDüsseldorf University HospitalCRChristoph RoderburgDüsseldorf University HospitalJJJulia K. JahnHochschule Bremerhaven

Discussion

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Implication

Depression burden in HF merits clinical attention; leaves open whether screening or treatment modifies progression.

Structured PICO

Does heart failure increase the incidence of depression and anxiety compared to common cancers in adult outpatients?

P
Population
163,990 adult outpatients (≥18 years) in Germany with an initial diagnosis of heart failure (n=96,772), breast cancer (n=21,261), prostate cancer (n=16,478), or digestive organ cancer (n=29,479). Excluded patients with prior depression/anxiety, prior other cancers, or <12 months observation time.
I
Intervention
Diagnosis of heart failure
C
Comparator
Diagnosis of breast, prostate, or digestive organ cancer
O
Outcome
Incidence of depression and anxiety disorders (investigated as a compound event) within 5 years after the index datecomposite

Heart failure is associated with a higher 5-year incidence of depression and anxiety compared to prostate and gastrointestinal cancers, highlighting the urgent need for integrated psycho-cardiology care.

Limitations

  • Accuracy of ICD codes is not statistically certain
  • Insufficient correlation between administrative documentation of diagnosis and prescribed antidepressants
  • Cannot exclude clustering of patient treatment strategies within hospitals and under physicians
  • Limited to ICD-10 coded diagnoses due to data protection

Cite This Study

Loosen et al. (2021) studied this question.

synapsesocial.com/papers/6a90e1eb5730a89ab2cae59dhttps://doi.org/10.1093/eurjpc/zwab048

Topics

Heart failureHFrEF treatmentCardio-oncology
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Depression risk in patients with heart failure in primary care practices in Germany2016 · 11 citations
  2. 2Minding the heart: Why are we still not closer to treating depression and anxiety in clinical cardiology practice?2017 · 20 citations
  3. 3Comorbidity health pathways in heart failure patients: A sequences-of-regressions analysis using cross-sectional data from 10,575 patients in the Swedish Heart Failure Registry2018 · 107 citations
  4. 4Depressive and Anxiety Symptoms Screening in Cardiac Inpatients: A Virtuous Italian Approach to Psychocardiology2020 · 27 citations
  5. 5Role of comorbidities in heart failure prognosis Part I: Anaemia, iron deficiency, diabetes, atrial fibrillation2020 · 71 citations