Why the study?
Does increased afterload via angiotensin infusion affect the left ventricular pressure fall during the isovolumic relaxation period in normal and diseased hearts?
Population
15 patients [normal (N): 5, valvular heart disease (VHD): 5, dilated cardiomyopathy (DCM): 5]
Comparison
Drip infusion of angiotensin to increase LV peak… vs Baseline measurements at rest
Design
Other
Authors
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Afterload effects on relaxation indices warrant cautious interpretation; leaves open clinical relevance in DCM.
Does increased afterload via angiotensin infusion affect the left ventricular pressure fall during the isovolumic relaxation period in normal and diseased hearts?
Afterload augmentation prolongs the time constant of left ventricular relaxation in normal and dilated cardiomyopathy patients, demonstrating the afterload dependence of isovolumic relaxation.
Katayama et al. (1988) studied this question.
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