January 1, 1996British Journal of PharmacologyOpen Access

Alterations in the force‐frequency relationship by tert‐ butylbenzohydroquinone, a putative SR Ca2+ pump inhibitor, in rabbit and rat ventricular muscle

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Population

isolated preparations from the rabbit and rat right ventricle

Comparison

30 microM 2,5 di--1,4-benzohydroquinone vs control conditions

Design

Preclinical

Authors

SBS. BaudetUniversité Paris-Sud EDEmmanuelle DoStanford University JNJacques NoireaudInserm

Discussion

Member takes

Implication

Supports SR Ca2+ uptake role in force-frequency responses; leaves open translation to human myocardium.

Structured PICO

Population

isolated preparations from the rabbit and rat right ventricle

Intervention

30 microM 2,5 di-(tert-butyl)-1,4-benzohydroquinone (TBQ)

Comparator

control conditions

Outcome

twitch tension, time course and SR Ca2+ content at different stimulation frequencies (0.5-3 Hz)surrogate

TBQ causes specific and partial inhibition of the SR Ca2+ pump in rabbit and rat ventricles, highlighting the importance of SR Ca2+ uptake in the force-frequency phenomenon.

Cite This Study

Baudet et al. (1996) studied this question.

synapsesocial.com/papers/6a90e367263aa8e25c73caf4 https://doi.org/10.1111/j.1476-5381.1996.tb15185.x

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Alterations in the force‐frequency relationship by tert‐ butylbenzohydroquinone, a putative SR Ca2+ pump inhibitor, in rabbit and rat ventricular muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Alterations in the force‐frequency relationship by tert‐ butylbenzohydroquinone, a putative SR Ca2+ pump inhibitor, in rabbit and rat ventricular muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider