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Clinical investigation reveals unchanged plasma and extracellular volumes during beta-blocker therapy in ischaemic heart disease, indicating these drugs do not induce fluid retention.
Plasma volume and extracellular volume (sodium space) were found to be unchanged during treatment with propranolol (nine patients) and practolol (four patients) for well-compensated ischaemic heart disease. The volumes were determined before treatment and 2 days and 3 months after optimal dose for each patient was reached.
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Hesse et al. (1974) studied this question.
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