Why the study?
Undetectable hs-cTn cutoffs to rule out MI may be defined differently among hospitals and are difficult to monitor, prompting evaluation of a clinical chemistry score versus hs-cTn alone.
Does a clinical chemistry score (CCS) improve diagnostic performance for hospital admission compared to hs-cTn alone in emergency department patients?
Population
Consecutive ED patients with glucose, creatinine, and hs-cTnI (n = 10496) or hs-cTnT (n = 25177)
Comparison
Clinical chemistry score vs hs-cTn alone
Design
Multicenter observational cohort study
Authors
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CCS may enhance early ED risk stratification for admission over hs-cTn alone; leaves open prospective validation before clinical adoption.
Does a clinical chemistry score (CCS) improve diagnostic performance for hospital admission compared to hs-cTn alone in emergency department patients?
A clinical chemistry score using presentation blood samples can effectively identify low- and high-risk emergency department patients for hospital admission, outperforming high-sensitivity troponin alone.
Kavsak et al. (2019) studied this question.
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