Fixed Combinations in Antihypertensive Therapy

A B S T R A C T Several studies have now confirmed that optimal targets of blood pressure (BP) could rarely be reached by monotherapy and various drug combinations are required to do this more effectively. However, the best way to increase patient compliance may be fixed combinations of two or more drugs in a single pill. With further research into mechanisms of action and development of new drugs, it became evident that the most effective combinations were those whose mechanisms are complementary or syner gistic. Thus, for the treatment of hypertension, the use of fixed combination therapy is gaining ground as a more practical and convenient approach for today’s clinical practice.