Why the study?
Does perfusion with magnesium ion solutions reduce the incidence of ventricular fibrillation following acute coronary occlusion in dogs?
Population
Dogs with acute coronary occlusion
Comparison
Perfusion of the ischemic area of the myocardium… vs Normal serum concentrations of magnesium in 5…
Design
Preclinical
Authors
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Magnesium solvent effects on post-occlusion VF require human validation before any clinical consideration; leaves open optimal formulation testing in ischemia models.
Does perfusion with magnesium ion solutions reduce the incidence of ventricular fibrillation following acute coronary occlusion in dogs?
Changes in extracellular magnesium and sodium ion concentrations may play a critical role in initiating ventricular fibrillation during acute myocardial ischemia.
GARDEN et al. (1957) studied this question.
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