Why the study?
Does the one-kidney, one-clip renovascular hypertension model alter regional blood flows and peripheral resistance in conscious rats?
Population
Conscious one-kidney, one-clip renovascular hypertensive rats with chronically implanted electromagnetic…
Comparison
One-kidney, one-clip renovascular hypertension… vs Control rats
Design
Preclinical
Authors
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These rat findings do not inform clinical hypertension management; leaves open renal compensation failure as a driver in renovascular disease.
Does the one-kidney, one-clip renovascular hypertension model alter regional blood flows and peripheral resistance in conscious rats?
In one-kidney, one-clip renovascular hypertensive rats, peripheral resistance is increased across vascular beds, suggesting the remaining renal area's failure to compensate for flow deprived by uni-nephrectomy plays a role in hypertension etiology.
Teranishi et al. (1988) studied this question.
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