February 1, 1998Pacing and Clinical Electrophysiology
Stability of the Defibrillation Probability Curve with the Development of Ventricular Dysfunction in the Canine Rapid Paced Model
Why the study?
Does ventricular dysfunction induced by rapid pacing alter defibrillation energy requirements in a canine model?
Population
16 dogs (11 paced to induce ventricular dysfunction, 5 unpaced controls)
Comparison
Ventricular pacing at 225 pulses/min for 2 weeks… vs Unpaced control dogs
Design
Preclinical
Follow-up
3 weeks (2 weeks pacing, 1 week post-pacing)
Authors
Discussion
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Implication
Defibrillation thresholds appear preserved despite pacing-induced systolic dysfunction; leaves open translation to human ICD energy settings in heart failure.
Structured PICO
Does ventricular dysfunction induced by rapid pacing alter defibrillation energy requirements in a canine model?
P
Population
16 dogs (11 paced to induce ventricular dysfunction, 5 unpaced controls)
I
Intervention
Ventricular pacing at 225 pulses/min for 2 weeks to induce ventricular dysfunction
C
Comparator
Unpaced control dogs
O
Outcome
Defibrillation energy requirements (defibrillation thresholds, ED20, ED50, and ED80)surrogate
The development of heart failure in a rapid paced canine model does not change the defibrillation efficacy of a biphasic transvenous system.
Cite This Study
Friedman et al. (1998) studied this question.