Key result
In a canine model, the atrial defibrillation threshold increased significantly after 8 hours of burst atrial pacing, reaching 124 +/- 33 V at 8 hours and 133 +/- 32 V at 48 hours (P < 0.05).
Why the study?
Does the duration of atrial fibrillation (burst pacing) increase atrial defibrillation thresholds in a canine model?
Population
26 mongrel dogs weighing 27.6 +/- 3.3 kg induced into AF by repeated high output burst atrial pacing
Comparison
Burst atrial pacing for varying durations… vs Comparison across different durations of burst…
Design
Preclinical
Follow-up
Up to 48 hours
Authors
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Hypothesis-generating in canine models; leaves open translation to human AF cardioversion thresholds.
Does the duration of atrial fibrillation (burst pacing) increase atrial defibrillation thresholds in a canine model?
p-value: p=< 0.05
In a canine model, atrial electrical remodeling and significant increases in atrial defibrillation thresholds are not observed until after 4 to 8 hours of burst atrial pacing.
Everett et al. (2001) studied Atrial fibrillation (n=26). Burst atrial pacing for varying durations vs. Shorter pacing durations was evaluated on Atrial defibrillation threshold (p=< 0.05). In a canine model, the atrial defibrillation threshold increased significantly after 8 hours of burst atrial pacing, reaching 124 +/- 33 V at 8 hours and 133 +/- 32 V at 48 hours (P < 0.05).
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