Why the study?
Are the ACE I/D and AGT M235T polymorphisms associated with an increased risk for coronary heart disease and myocardial infarction?
Are the ACE I/D and AGT M235T polymorphisms associated with an increased risk for coronary heart disease and myocardial infarction?
The ACE DD and AGT TT genotypes may be associated with increased risk of CHD and MI in specific subgroups, but the association is not strong or consistent across populations.
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AGT TT may raise CHD risk in Caucasians; leaves open replication, generalizability, and any clinical role.
Ludwig et al. (1997) studied this question.
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