Why the study?
Is the ACE gene polymorphism associated with essential hypertension based on ambulatory blood pressure monitoring?
Is the ACE gene polymorphism associated with essential hypertension based on ambulatory blood pressure monitoring?
The ACE gene polymorphism does not appear to be associated with essential hypertension or variations in ambulatory blood pressure levels.
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ACE polymorphism shows no link to hypertension or ABP levels; hypothesis-generating and should not alter clinical practice.
The association of the angiotensin converting enzyme (ACE) gene polymorphism with essential hypertension is still controversial. We studied its polymorphism in 41 patients with hypertension based on ambulatory blood pressure (ABP) and 34 subjects with normal blood pressure. The ACE genotype was not significantly different between hypertensive and normotensive subjects. Casual blood pressure levels, 24 h, and daytime and nighttime ABP levels did not differ among the ACE genotype in patients with hypertension. In conclusion, the ACE genotype is not associated with essential hypertension based on ABP monitoring.
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Yoshikazu Maeda (1997) studied this question.
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