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December 1, 1988AJP Heart and Circulatory Physiology

Regional variation in pericardial contact pressure in the canine ventricle

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Population

8 open-chest dogs

Design

Preclinical

Authors

BHBrian D. HoitCardiac ImagingWLWilbur Y.W. LewVeterans Medical Research Foundation of San DiegoMLMartin M. LeWinterHeart Failure & Transplant

Discussion

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Overview

Regional pericardial pressure heterogeneity may invalidate single-site restraint estimates; leaves open human validation in HF.

Key Points

  • To determine whether pericardial contact pressure varies across different ventricular regions in response to changes in cardiac volume.
  • Studied eight open-chest dogs (N=8) using flat, air-filled balloons to record simultaneous pericardial contact pressure over the lateral right and left ventricles during dextran infusion.
  • Evaluated pressure changes after transecting pericardial diaphragmatic attachments, repositioning dogs into dependent orientations, placing balloons across multiple ventricular sites, and performing aortic or pulmonary artery occlusions.
  • End-diastolic pericardial contact pressure was significantly higher over the lateral left ventricle than the lateral right ventricle at high left atrial pressures (9.1 +/- 2.4 mmHg vs. 4.3 +/- 2.3 mmHg, P < 0.05) and middle left atrial pressures (6.2 +/- 3.5 mmHg vs. 1.5 +/- 2.4 mmHg, P < 0.05).
  • Pericardial contact pressure was consistently higher over the lateral left ventricular wall than over the anterior or posterior walls, and selectively increased over the left ventricle during aortic occlusion and over the right ventricle during pulmonary artery occlusion.

Structured PICO

P
Population
8 open-chest dogs
I
Intervention
Measurement of pericardial contact pressure using flat, air-filled balloons over lateral walls of right and left ventricles while cardiac volume was varied by dextran infusion, aortic occlusion, and pulmonary artery occlusion
O
Outcome
Regional variation in pericardial contact pressure (PCP)surrogate

Pericardial pressure varies regionally, indicating that a single pericardial pressure measurement may oversimplify pericardial restraint on cardiac volume.

Cite This Study

Hoit et al. (1988) studied this question.

synapsesocial.com/papers/6a912998fbd14437d06f1cd2https://doi.org/10.1152/ajpheart.1988.255.6.h1370
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nonuniformity of pericardial surface pressure in dogs.1987 · 60 citations
  2. 2Nonuniform regional deformation of the pericardium during the cardiac cycle in dogs.1990 · 15 citations
  3. 3Pericardial influences on ventricular filling in the conscious dog. An analysis based on pericardial pressure.1984 · 63 citations
  4. 4Assessment of pericardial constraint in dogs.1985 · 144 citations
  5. 5Right and left ventricular pressure-volume response to elevated pericardial pressure.1986 · 15 citations