Key result
In postmortem canine hearts, right ventricular transmural pressures were always positive and increased with volume, indicating the right ventricle is not unstressed over physiologic volumes.
Population
Six canine hearts examined postmortem
Design
Preclinical
Authors
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Challenges unstressed RV assumption in volume models; leaves open whether pericardial pressure estimates require revision in humans.
The right ventricle is not unstressed over the physiologic range of volumes, suggesting that pericardial balloon pressures may overestimate pericardial pressure and right atrial pressure cannot reliably estimate it.
Santamore et al. (1987) studied Assessment of right ventricular transmural pressure (n=6). Direct measurement of ventricular pressure-volume curves was evaluated on Right and left ventricular transmural pressures at varying volumes. In postmortem canine hearts, right ventricular transmural pressures were always positive and increased with volume, indicating the right ventricle is not unstressed over physiologic volumes.
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