Why the study?
Does cortisone or ACTH alter susceptibility to poliomyelitis infection in hamsters and mice?
Does cortisone or ACTH alter susceptibility to poliomyelitis infection in hamsters and mice?
Cortisone, alone or with ACTH, markedly enhances susceptibility to and accelerates poliomyelitis infection in mice and hamsters, leading to fatal disease.
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Steroids may heighten poliomyelitis susceptibility in animals; leaves open human translation and clinical relevance.
ACTH and cortisone in combination or cortisone alone produce a marked acceleration of poliomyelitis infection (strain MEF1) in mice and an extraordinary enhancement of susceptibility to this infection in hamsters giving rise to a violent and uniformly fatal disease. ACTH alone fails to produce this effect possibly due to elaboration of an unknown factor capable of reversing the enhancing effect of cortisone. The experiments seem to indicate the existence of a significant relation between adrenocortical function and susceptibility of mice and hamsters to experimental poliomyelitis.
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Gregory Shwartzman (1950) studied this question.
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