Population
Pregnant mice at 6-7 days of gestation (murine model of congenital enterovirus infection)
Comparison
Intravenous inoculation with Theiler's murine… vs Intravenous inoculation with BHK 21 cell lysate
Design
Preclinical
Follow-up
6 or 12 days post-inoculation
Authors
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Does not support practice change; murine data leave open whether enterovirus increases human placental-fetal loss.
Maternal enterovirus infection in a murine model causes significant placental and fetal abnormalities and pregnancy loss, likely through both direct fetal damage and placental compromise.
Palmer et al. (1997) studied this question.
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