Why the study?
Does the Nimbus axial flow blood pump provide adequate hemodynamic support and biocompatibility in a sheep model?
Population
14 sheep (6 acute experiments < 6 hr, 8 short-term survival studies up to 6 days)
Design
Preclinical
Follow-up
up to 6 days
Authors
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AxiPump feasible for complete support in sheep; leaves open need for anticoagulation and design refinements to mitigate thrombosis before translation.
Does the Nimbus axial flow blood pump provide adequate hemodynamic support and biocompatibility in a sheep model?
The Nimbus axial flow blood pump can provide complete circulatory support in a sheep model, but requires design changes and anticoagulation to prevent thrombosis and renal infarction.
Antaki et al. (1993) studied this question.
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