Key result
In a sheep supported with an axial flow LVAD, total arterial resistance was significantly lower when standing compared to sitting (P<0.01) and higher during agitation than normal temper (P<0.01).
Population
A sheep model implanted with an axial flow LVAD (n=1)
Comparison
Nimbus AxiPump support for 28 days vs Different physiological states
Design
Preclinical
Follow-up
28 days
Authors
Loading...
SVR changes with posture and agitation in axial LVAD sheep; leaves open whether adaptive pump speed algorithms are needed in humans.
p-value: p=<0.01
In a sheep model supported by an axial flow LVAD, systemic vascular resistance changes appropriately in response to physiologic stimuli despite diminished pulsatility, suggesting pump speed control must compensate for SVR changes.
Konishi et al. (1994) studied LVAD support (n=1). Nimbus AxiPump was evaluated on Total arterial resistance (TR) changes in response to posture and excitability (p=<0.01). In a sheep supported with an axial flow LVAD, total arterial resistance was significantly lower when standing compared to sitting (P<0.01) and higher during agitation than normal temper (P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: