Combined treatment with anticholinergics and levodopa/carbidopa may be effective for catatonic-like behavior and extrapyramidal sequelae in neuroleptic malignant syndrome.
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May suggest therapeutic option for NMS catatonia; hypothesis-generating single case leaves efficacy open.
The clinical manifestations, differential diagnosis, and treatment of the neuroleptic malignant syndrome and neuroleptic-induced catatonia are discussed. A case is presented in which the catatonic-like behavior and extrapyramidal sequelae of the neuroleptic malignant syndrome responded to combined treatment with anticholinergics and levodopa/carbidopa. Differential diagnosis and theories regarding the development of these neuroleptic-induced disorders are reviewed.
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Stoudemire et al. (1985) studied this question.
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