Why the study?
Does [Sar1, Ala8]angiotensin II (P-113) improve renal blood flow and decrease renal vascular resistance in the contralateral kidney during partial occlusion of the renal artery in dogs?
Population
Dogs anesthetized with pentobarbital or morphine chloralose-urethan with induced partial occlusion of the…
Comparison
[Sar1, Ala8]angiotensin II administered… vs Baseline state before partial occlusion of the…
Design
Preclinical
Follow-up
Up to 122 minutes after initiation of RAO
Authors
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Supports angiotensin II mediation of contralateral renal vasoconstriction during unilateral RAO in dogs; leaves open translation to human renovascular disease.
Does [Sar1, Ala8]angiotensin II (P-113) improve renal blood flow and decrease renal vascular resistance in the contralateral kidney during partial occlusion of the renal artery in dogs?
In a canine model, the angiotensin II antagonist P-113 reverses the increase in contralateral renal vascular resistance induced by unilateral renal artery occlusion, highlighting the role of angiotensin in mediating this response.
Satoh et al. (1975) studied this question.
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