Thresholds of Toxicological Concern Based on Structure-Activity Relationships

I.C. Munro; R.A. Ford; Elke Kennepohl; James G. Sprenger

doi:10.3109/03602539608994000

January 1, 1996Drug Metabolism Reviews

Thresholds of Toxicological Concern Based on Structure-Activity Relationships

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Key Points

Establish chemical exposure thresholds of toxicological concern using structural classifications and toxicological potency data.
Review structural characteristics and functional groups across diverse chemical compounds associated with adverse toxicological outcomes.
Analyze the relationship between molecular structure classes and historical toxicology databases to delineate safe exposure limits.
Chemical classes demonstrate clear, predictable distributions of toxic potency based on specific molecular features and reactivity.
Tiered exposure thresholds provide reliable human safety cutoffs for chemicals present at low levels without extensive experimental testing.

Implication

Toxicological review demonstrates chemical safety benchmarks based on structure-activity relationships, highlighting exposure thresholds for compounds lacking complete toxicity profiles.

Abstract

(1996). Thresholds of Toxicological Concern Based on Structure-Activity Relationships. Drug Metabolism Reviews: Vol. 28, No. 1-2, pp. 209-217.

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Cite This Study

Munro et al. (1996) studied this question.

synapsesocial.com/papers/6a914c831ff55ae0aec6574e https://doi.org/10.3109/03602539608994000

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Thresholds of Toxicological Concern Based on Structure-Activity Relationships

Key Points

Implication

Abstract

Discussion

Cite This Study

Thresholds of Toxicological Concern Based on Structure-Activity Relationships

Key Points

Implication

Abstract

Discussion

Cite This Study

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