Why the study?
Does maternal sleep restriction during late pregnancy alter cardiovascular autonomic regulation and renal function in adult male offspring?
Population
Male offspring of female Wistar rats
Comparison
Maternal sleep restriction using the multiple… vs Offspring from control mothers without sleep…
Design
Preclinical, randomly assigned
Follow-up
Up to 4 months of age
Key result
Maternal sleep restriction during late pregnancy increased blood pressure, glomerular filtration rate, and sympathetic cardiac tone, and reduced baroreflex sensitivity in adult male offspring.
Authors
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Does not support changes in prenatal care; hypothesis-generating for developmental programming of hypertension, needing human studies.
RCT
randomly assigned
Does maternal sleep restriction during late pregnancy alter cardiovascular autonomic regulation and renal function in adult male offspring?
Maternal sleep restriction during late pregnancy induces long-term cardiovascular autonomic and renal morpho-functional alterations in offspring, leading to increased blood pressure.
Raimundo et al. (2016) conducted an RCT in Maternal sleep restriction. Sleep restriction vs. Control group was evaluated on Renal function and autonomic responses. Maternal sleep restriction during late pregnancy increased blood pressure, glomerular filtration rate, and sympathetic cardiac tone, and reduced baroreflex sensitivity in adult male offspring.