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June 1, 1984Proceedings of the National Academy of SciencesOpen Access

Proteolysis and structure of skeletal muscle actin.

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Population

Rabbit skeletal muscle F-actin

Design

Preclinical

Authors

DMDominique MornetCentre National de la Recherche ScientifiqueKUKathleen UeUniversity of the Pacific

Discussion

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Overview

Maps actin domains in animal models; leaves open extension to human cardiac actin function.

Structured PICO

P
Population
Rabbit skeletal muscle F-actin
I
Intervention
Proteolysis with nine different proteases (trypsin, chymotrypsin, thermolysin, nagarse, proteinase K, plasmin, S. aureus V8, clostripain, thrombin)
O
Outcome
Pattern of fragments produced by proteolysis, studied by NaDodSO4 gel electrophoresis

The actin monomer consists of a 33 kDa protease-resistant region and a 9 kDa protease-vulnerable region, which helps explain numerous properties of actin assembly and function.

Cite This Study

Mornet et al. (1984) studied this question.

synapsesocial.com/papers/6a916403b108026aa1fb6721https://doi.org/10.1073/pnas.81.12.3680
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Three-dimensional structure of the complex of skeletal muscle actin and bovine pancreatic DNAse I at 6-A resolution.1981 · 102 citations
  2. 2Troponin-Tropomyosin Complex1974 · 486 citations
  3. 3Identification of myosin-binding sites on the actin sequence1982 · 327 citations
  4. 4ATP binding to a protease-resistant core of actin.1976 · 109 citations
  5. 5Carp Muscle Calcium-binding Protein1973 · 1,361 citations