Key result
Age > 65 years (OR 2.81), PVOI ≥ 25% at diagnosis (OR 3.53), elevated factor VIII (OR 3.89), and chronic respiratory disease (OR 2.18) independently predicted residual pulmonary vascular obstruction.
Why the study?
Risk factors for residual pulmonary vascular obstruction following a first unprovoked pulmonary embolism had not been clearly identified.
What are the independent predictors for residual pulmonary vascular obstruction 6 months after a first unprovoked pulmonary embolism?
Population
371 patients with a first unprovoked PE initially treated for 6 uninterrupted months
Comparison
Predictors of residual pulmonary vascular obstruction
Design
Post hoc analysis of a double-blind randomized trial
Authors
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May inform selective post-PE imaging follow-up; extends predictor identification within RCT data.
RCT (n=371)
Double-blind
Randomized
What are the independent predictors for residual pulmonary vascular obstruction 6 months after a first unprovoked pulmonary embolism?
Odds Ratio: 2.81 (95% CI 1.58–5)
Age > 65, high initial clot burden, elevated factor VIII, and chronic respiratory disease strongly predict residual pulmonary vascular obstruction 6 months after unprovoked PE.
Raj et al. (2019) conducted an RCT in First unprovoked pulmonary embolism (n=371). Age > 65 years vs. Age ≤ 65 years was evaluated on Residual pulmonary vascular obstruction index (PVOI) ≥ 5% (OR 2.81, 95% CI 1.58-5.00). Age > 65 years (OR 2.81), PVOI ≥ 25% at diagnosis (OR 3.53), elevated factor VIII (OR 3.89), and chronic respiratory disease (OR 2.18) independently predicted residual pulmonary vascular obstruction.
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