Key result
Age ≥65 and chronic respiratory failure are linked to >2-fold higher odds of post-PE residual obstruction.
Why the study?
The prevalence of residual pulmonary vascular obstruction after symptomatic pulmonary embolism and its risk factors were not well defined.
Population
537 patients with acute PE undergoing ventilation/perfusion lung scan at 3 to 24 months follow-up
Comparison
Patients with RPVO ≥ 5% versus those without RPVO ≥ 5%
Design
Prospective cohort study
Follow-up
3 to 24 months
Authors
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May support closer post-PE surveillance in select patients; leaves open whether these predictors guide interventions or require prospective validation.
Cohort (n=537)
Odds Ratio: 2.25 (95% CI 1.45–3.52)
Age ≥ 65 years, chronic respiratory failure, unprovoked PE, and initial pulmonary vascular obstruction ≥ 20% are independent risk factors for residual pulmonary vascular obstruction after acute PE.
Picart et al. (2020) conducted a cohort in Symptomatic pulmonary embolism (n=537). Age ≥ 65 years vs. Age < 65 years was evaluated on Residual pulmonary vascular obstruction (RPVO) ≥ 5% (OR 2.25, 95% CI 1.45-3.52). Age ≥ 65 years (OR 2.25; 95% CI 1.45-3.52) and chronic respiratory failure (OR 3.19; 95% CI 1.22-10.04) were independent predictors of residual pulmonary vascular obstruction ≥ 5% after PE.
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