Key result
An escalating-dose defibrillation strategy (200-360 J) achieved higher rates of successful defibrillation compared to fixed 150-J shocks in an ischemic VF swine model (83% vs 29%; p<0.002).
Why the study?
Does an escalating-dose defibrillation strategy improve successful defibrillation in a swine model of ischemically induced ventricular fibrillation compared to a fixed-dose strategy?
Population
46 swine with ischemically induced ventricular fibrillation
Comparison
Escalating, higher-energy transthoracic shocks… vs Fixed, lower-energy transthoracic shocks with a…
Design
Preclinical, randomized
Authors
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Hypothesis-generating for escalating defibrillation in ischemic VF; prospective human trials needed before adoption.
RCT (n=46)
randomized
Does an escalating-dose defibrillation strategy improve successful defibrillation in a swine model of ischemically induced ventricular fibrillation compared to a fixed-dose strategy?
Absolute Event Rate: 83% vs 29%
p-value: p=< 0.002
In a swine model of ischemic VF, an escalating-dose defibrillation strategy was significantly more effective for prompt defibrillation than a fixed, lower-energy strategy.
Niemann et al. (2004) conducted an RCT in Ischemically induced ventricular fibrillation (n=46). Escalating-dose defibrillation vs. Fixed-dose defibrillation (150 J) was evaluated on Successful defibrillation (termination of VF for 5 seconds) with ≤3 shocks (p=< 0.002). An escalating-dose defibrillation strategy (200-360 J) achieved higher rates of successful defibrillation compared to fixed 150-J shocks in an ischemic VF swine model (83% vs 29%; p<0.002).
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