Key result
The ADRA2B I/D polymorphism was not consistently associated with metabolic syndrome, but D-allele carriers had significantly higher diastolic blood pressure.
Why the study?
Is the ADRA2B I/D polymorphism or chromosome 2q12 region associated with metabolic syndrome or its components in middle-aged Swedes?
Observational (n=5,543)
Is the ADRA2B I/D polymorphism or chromosome 2q12 region associated with metabolic syndrome or its components in middle-aged Swedes?
Answers are grounded in this paper and cite their sources.
The ADRA2B I/D polymorphism is associated with higher diastolic blood pressure but not metabolic syndrome in middle-aged Swedes, while chromosome 2q12 shows linkage to pulse pressure and waist/hip ratio.
OBJECTIVE: To test whether a previously hypertension-linked 23 cM region on chromosome 2 is linked to the metabolic syndrome (MetS) or its individual components, and whether a common I/D polymorphism of the adrenergic receptor 2b (ADRA2B) gene, mapping in that region, is associated with the same traits. METHODS: We conducted fine mapping of the hypertension-linked region on chromosome 2 spanning between 107 and 130 cM using 11 informative polymorphic markers in 260 healthy white siblings belonging to 118 nuclear families. Variance-component linkage analysis was performed for each MetS component and a composite sum of MetS phenotypes as quantitative trait after adjustment for significant covariates using 'Solar software package'. Successively, the I/D polymorphism of the ADRA2B gene was genotyped in 5283 patients in the Malmö Diet and Cancer-cardiovascular arm, seeking for association with the MetS using standard definitions and separately, with its individual components. RESULTS: For 24-h pulse pressure and waist/hip ratio, LOD [logarithm of the odds (to the base 10)] scores of more than two were found between 107 and 122 cM on chromosome 2. For the composite sum of MetS phenotypes, LOD score of more than 1 was found between 116 and 120 cM. There was no difference between carriers and noncarriers of the D-allele of the ADRA2B gene in MetS prevalence but D-carriers were associated with significantly higher levels of diastolic blood pressure. CONCLUSION: Our results suggest that chromosome 2 could harbor one or more genes implied in blood pressure homeostasis and MetS development. The ADRA2B I/D polymorphism is not consistently associated with MetS and metabolic/anthropometric parameters but with diastolic blood pressure in an urban-based population of middle-aged Swedes.
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Fava et al. (2009) conducted an observational in Metabolic syndrome and hypertension (n=5,543). ADRA2B I/D polymorphism (D-allele carrier) vs. Noncarriers of the D-allele was evaluated on Metabolic syndrome prevalence and individual components (e.g., diastolic blood pressure). The ADRA2B I/D polymorphism was not consistently associated with metabolic syndrome, but D-allele carriers had significantly higher diastolic blood pressure.
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