Why the study?
Does aminophylline administration increase myocardial cyclic AMP and induce ventricular fibrillation in a dog model?
Does aminophylline administration increase myocardial cyclic AMP and induce ventricular fibrillation in a dog model?
Aminophylline administration in dogs increases myocardial cyclic AMP levels, which is significantly associated with the induction of ventricular fibrillation.
Associates higher myocardial cAMP with aminophylline-induced VF in dogs; hypothesis-generating and should not yet inform clinical practice.
The concentration of myocardial cyclic AMP was measured in 9 dogs by radioimmunoassay after the administration of aminophylline. Fourteen dogs served as control. The concentration of cyclic AMP in the left ventricle was the highest and the lowest value was obtained in the right atrium in the control dogs. Ventricular fibrillations were induced immediately after the injection of 30 mg/Kg aminophylline in 3 dogs out of 9. The concentration of the left ventricular cyclic AMP in 6 dogs which tolerated aminophylline was significantly elevated compared with that of the control dogs (p less than 0.05). The left ventricular cyclic AMP in 3 dogs with ventricular fibrillation was significantly higher compared with that in the aminophylline tolerated dogs with non-fibrillating hearts (p less than 0.01). These results showed that the concentration of cyclic AMP was elevated in the fibrillating heart.
No takes yet. Share an insight, caveat, or question.
Sugiura et al. (1979) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: