Key result
High intensity interval training combined with continuous glucose monitoring did not significantly increase the primary endpoint of adrenaline response to hypoglycemia compared to monitoring alone (1130 vs -298 pmol/l, p=0.11).
Why the study?
It was unknown whether 4 weeks of high intensity interval training has sustained effects on counterregulatory and symptom responses to hypoglycaemia in adults with type 1 diabetes and impaired awareness of hypoglycaemia.
Does 4 weeks of high intensity interval training (HIIT) combined with RT-CGM improve hypoglycaemia-induced adrenaline responses in adults with type 1 diabetes and impaired awareness of hypoglycaemia compared to RT-CGM alone?
RCT (n=18)
Open-label
Web-based system
No
Does 4 weeks of high intensity interval training (HIIT) combined with RT-CGM improve hypoglycaemia-induced adrenaline responses in adults with type 1 diabetes and impaired awareness of hypoglycaemia compared to RT-CGM alone?
Absolute Event Rate: 1130% vs -298%
p-value: p=0.11
A 4-week high intensity interval training program in adults with type 1 diabetes and impaired awareness of hypoglycemia improved noradrenergic, glucagon, and symptomatic responses to subsequent hypoglycemia, though it did not significantly increase the primary endpoint of adrenaline response.
No takes yet. Share an insight, caveat, or question.
HIIT may enhance CRR and symptoms in T1D with IAH without increasing hypo exposure; hypothesis-generating, larger trials needed before practice change.
Farrell et al. (2023) conducted an RCT in Type 1 diabetes with impaired awareness of hypoglycaemia (n=18). High intensity interval training (HIIT) plus real-time continuous glucose monitoring (RT-CGM) vs. Real-time continuous glucose monitoring (RT-CGM) alone was evaluated on Difference in hypoglycaemia-induced adrenaline (epinephrine) responses from baseline (p=0.11). High intensity interval training combined with continuous glucose monitoring did not significantly increase the primary endpoint of adrenaline response to hypoglycemia compared to monitoring alone (1130 vs -298 pmol/l, p=0.11).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: