Why the study?
Does ethmozine have different effects on transmembrane action potentials and use-dependent block compared to flecainide and encainide in canine Purkinje fibers?
Population
Canine Purkinje fibers
Comparison
Flecainide, encainide, and ethmozine vs Comparison between the drugs
Design
Preclinical
Authors
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Ethmozine’s kinetics may inform class Ic safety differences; leaves open translation from canine fibers to clinical proarrhythmia risk.
Does ethmozine have different effects on transmembrane action potentials and use-dependent block compared to flecainide and encainide in canine Purkinje fibers?
The faster onset and recovery from use-dependent block of ethmozine compared to flecainide and encainide may explain its lack of proarrhythmic effects seen in the Cardiac Arrhythmia Suppression Trial.
Lee et al. (1991) studied this question.
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