What is the clinical evidence from this study?

Study design: Observational. Population: Healthy individuals and patients with clinical indications for catheterization (n=113). Intervention: Non-invasive cardiovascular profiling (HDI/Pulsewave CR-2000) vs. Invasive hemodynamic measurements. Primary outcome: Repeatability of large (C1) and small (C2) arterial elasticity indices (p=NS).

What question did this study set out to answer?

To evaluate the repeatability of non-invasive large and small arterial elasticity indices over short and intermediate timeframes and compare non-invasive hemodynamic measurements to invasive catheterization.

August 1, 2002Blood Pressure Monitoring

Assessment of repeatability and correlates of arterial compliance

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Key result

Non-invasive cardiovascular profiling using the HDI/Pulsewave CR-2000 system demonstrated short- and intermediate-term repeatability for arterial elasticity indices and agreed with invasive measures.

Why the study?

Is the HDI/Pulsewave CR-2000 Research CardioVascular Profiling System repeatable and does it agree with invasive hemodynamic measurements?

Population

113 individuals, comprising 90 healthy hospital employees and 23 patients undergoing right and left heart…

Comparison

Non-invasive cardiovascular profiling using the… vs Invasive hemodynamic measurements and repeated…

Design

Cross-sectional

Follow-up

Up to average 52 days

Authors

LPL. Michael PrisantRush University Medical Center MPMohit PasiAugusta University DJDena JupinUniversity of Georgia

Discussion

Member takes

Implication

Cautions against routine clinical adoption; leaves open prospective validation of non-invasive arterial elasticity profiling.

Key Points

To evaluate the repeatability of non-invasive large and small arterial elasticity indices over short and intermediate timeframes and compare non-invasive hemodynamic measurements to invasive catheterization.
Assessed short-term repeatability in 31 healthy hospital employees tested twice within 1 hour, and intermediate repeatability in 59 healthy hospital employees tested twice an average of 52 days apart using the HDI/Pulsewave CR-2000 system.
Compared non-invasive cardiovascular profiling metrics against invasive right and left heart catheterization measurements in 23 patients undergoing routine clinical evaluation.
Short-term repeatability testing showed no significant differences for large artery compliance (mean difference +0.25 ± 2.83 ml/mmHg × 10; P = NS) or small artery compliance (mean difference -0.14 ± 1.86 ml/mmHg × 100; P = NS).
Intermediate-term repeatability testing similarly revealed non-significant changes for large artery compliance (mean difference -0.415 ± 2.97 ml/mmHg × 10; P = NS) and small artery compliance (mean difference -0.19 ± 2.67 ml/mmHg × 100; P = NS).
Invasive catheterization yielded significantly lower measurements than non-invasive assessment for both aortic diastolic blood pressure (-4.74 ± 9.7 mmHg) and systemic vascular resistance (-194 ± 264 dyne · s · cm⁻⁵).

Study Design

Type

Observational (n=113)

Structured PICO

Is the HDI/Pulsewave CR-2000 Research CardioVascular Profiling System repeatable and does it agree with invasive hemodynamic measurements?

Population

113 participants, including 90 healthy hospital employees and 23 patients undergoing routine heart catheterization, assessed for arterial compliance repeatability.

Exposure

Non-invasive cardiovascular profiling using the HDI/Pulsewave CR-2000 Research CardioVascular Profiling System.

Comparator

Invasive hemodynamic measurements (for the catheterization group) and repeated non-invasive measurements (for repeatability groups).

Outcome

Repeatability of large (C1) and small (C2) arterial elasticity indices and agreement between non-invasive and invasive hemodynamic parameters.surrogate

Main Result

p-value: p=NS

The HDI/Pulsewave CR-2000 system provides repeatable non-invasive measurements of arterial elasticity that reasonably agree with invasive hemodynamic assessments.

Cite This Study

Prisant et al. (2002) conducted an observational in Healthy individuals and patients with clinical indications for catheterization (n=113). Non-invasive cardiovascular profiling (HDI/Pulsewave CR-2000) vs. Invasive hemodynamic measurements was evaluated on Repeatability of large (C1) and small (C2) arterial elasticity indices (p=NS). Non-invasive cardiovascular profiling using the HDI/Pulsewave CR-2000 system demonstrated short- and intermediate-term repeatability for arterial elasticity indices and agreed with invasive measures.

synapsesocial.com/papers/6a91929b6311dd658ec64f6f https://doi.org/10.1097/00126097-200208000-00005

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Assessment of repeatability and correlates of arterial compliance

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Assessment of repeatability and correlates of arterial compliance

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

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Also Consider