Key result
Haptoglobin (Hp1-1) and MnSOD Val/Ala gene polymorphisms were associated with essential hypertension in a Brazilian population, whereas ACE genotypes showed no association.
Why the study?
Is there an association between specific gene polymorphisms (haptoglobin, ACE, GSTM1, GSTT1, MnSOD, CAT, GPX1) and essential hypertension in an urban Brazilian population?
Case-Control
Is there an association between specific gene polymorphisms (haptoglobin, ACE, GSTM1, GSTT1, MnSOD, CAT, GPX1) and essential hypertension in an urban Brazilian population?
In an urban Brazilian population, essential hypertension may be associated with Hp1-1 and MnSOD Val/Ala genotypes, highlighting a potential role for oxidative stress-related polymorphisms.
Essential hypertension is a complex and multifactorial trait; genetic and environmental factors interact to produce the final phenotype. Studies have demonstrated association of hypertension with varied gene polymorphisms. However, demonstration of common genetic causes in the general population remains elusive. We investigated a possible association between hypertension and haptoglobin, angiotensin I-converting enzyme (ACE), glutathione S-transferases GSTM1 and GSTT1, MnSOD (Val9Ala), CAT (-21A/T), and GPX1 (Pro198Leu) gene polymorphisms in an urban Brazilian population group from Brasília. Although ACE has been reported to be one of the main polymorphisms associated with hypertension, we found no association with ACE's specific genotypes. However, a possible association with Hp1-1 and MnSOD Val/Ala genotypes suggests that, at least for the Brazilian population, polymorphisms related to oxidative stress should be more deeply investigated.
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Miranda‐Vilela et al. (2010) conducted a case-control in Essential hypertension. Gene polymorphisms (haptoglobin, ACE, GSTM1, GSTT1, MnSOD, CAT, GPX1) was evaluated on Association with essential hypertension. Haptoglobin (Hp1-1) and MnSOD Val/Ala gene polymorphisms were associated with essential hypertension in a Brazilian population, whereas ACE genotypes showed no association.
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