What question did this study set out to answer?

Investigate intercostal muscle end-plate morphology in patients diagnosed with amyotrophic lateral sclerosis (ALS) compared to benign motor neuron disease (MND) and controls.

October 1, 1975Archives of Neurology

End-Plate Morphology in Amyotrophic Lateral Sclerosis

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Authors

EBE. K. BjornskovPresbyterian Medical Center NDN. P. Dekker FNF. H. NorrisNational Institutes of Health

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Implication

Comparative study reveals increased segmented end-plates in motor neuron diseases, indicating neuromuscular junction alterations that do not correlate with clinical variables.

Key Points

Investigate intercostal muscle end-plate morphology in patients diagnosed with amyotrophic lateral sclerosis (ALS) compared to benign motor neuron disease (MND) and controls.
Measured intact and segmented intercostal muscle end-plates in patients with ALS, benign MND, and control subjects.
Analyzed the relationship between observed end-plate morphological abnormalities and relevant clinical variables in ALS cases.
Intact end-plate length in ALS and benign MND did not differ from control values.
Segmented end-plates were elevated in both ALS and benign MND, with the greatest overall end-plate length detected in ALS.
No correlation was found between the severity of end-plate structural abnormalities and clinical variables in individual ALS cases.

Cite This Study

Bjornskov et al. (1975) studied this question.

synapsesocial.com/papers/6a91972dbd296d8bc5121835 https://doi.org/10.1001/archneur.1975.00490520081016

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Implication

Comparative study reveals increased segmented end-plates in motor neuron diseases, indicating neuromuscular junction alterations that do not correlate with clinical variables.

End-Plate Morphology in Amyotrophic Lateral Sclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

End-Plate Morphology in Amyotrophic Lateral Sclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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