Key result
Heterozygous substitutions at the AGT M235T and REN A/G(I8-83) loci were significantly associated with end-stage renal disease compared to homozygous common genotypes (p=0.005 and p=0.023).
Why the study?
Do M235T polymorphism in the AGT gene and A/G(I8-83) polymorphism in the REN gene correlate with end-stage renal disease?
Case-Control (n=502)
Do M235T polymorphism in the AGT gene and A/G(I8-83) polymorphism in the REN gene correlate with end-stage renal disease?
Heterozygous substitutions at the AGT M235T and REN A/G(I8-83) loci correlate significantly with ESRD in a north Indian population.
These polymorphisms may mark ESRD risk in north Indians; hypothesis-generating and should not change practice.
BACKGROUND/AIMS: This study aimed at investigating if M235T polymorphism in the AGT gene and A/G(I8-83) polymorphism in the REN gene correlate with end-stage renal disease (ESRD). METHODS: We analyzed 173 ESRD patients and 329 individuals with normal kidney function for differences in the genotype distribution of AGT-M235T and REN-A/G(I8-83) polymorphisms between the two groups. The data for cases and controls were compared using the χ(2) test. RESULTS: We found significantly higher levels of serum creatinine and CRP in cases in comparison to controls (p < 0.0001). Data comparison showed a significant association of AGT M235T substitution with ESRD in the dominant model (p = 0.008) and in the comparison of the heterozygous substitution with the homozygous common genotype (p = 0.005). Similarly, REN A/G(I8-83) polymorphism showed a significant difference in the distribution of genotypes between cases and controls (p < 0.038) such that a heterozygous substitution was significantly more common in the ESRD cases in comparison to the homozygous common genotype (p = 0.023). CONCLUSION: We conclude that heterozygous substitutions at the AGT M235T and REN A/G(I8-83) loci correlate significantly with ESRD in a north Indian population.
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Sarkar et al. (2015) conducted a case-control in End-stage renal disease (n=502). AGT M235T and REN A/G(I8-83) polymorphisms vs. Homozygous common genotype was evaluated on End-stage renal disease (ESRD) (p=0.008). Heterozygous substitutions at the AGT M235T and REN A/G(I8-83) loci were significantly associated with end-stage renal disease compared to homozygous common genotypes (p=0.005 and p=0.023).
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