Key result
ACE insertion/deletion polymorphism was not significantly associated with obesity, hypertension, insulin resistance, or metabolic syndrome in Egyptian females.
Why the study?
Is ACE I/D polymorphism associated with obesity, hypertension, insulin resistance, and metabolic syndrome in Egyptian females?
Population
80 Egyptian female volunteers
Comparison
Angiotensin-converting enzyme insertion/deletion… vs Controls
Design
Case-control
Authors
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ACE I/D polymorphism should not guide obesity or hypertension care in Egyptian females; leaves open possible I-allele protection in normal fat distribution.
Case-Control (n=80)
No
Is ACE I/D polymorphism associated with obesity, hypertension, insulin resistance, and metabolic syndrome in Egyptian females?
In Egyptian females, ACE I/D polymorphism is not significantly associated with obesity or metabolic syndrome, though the I allele may be protective against hypertension in subjects with normal fat distribution.
Motawi et al. (2016) conducted a case-control in Obesity and related disorders (n=80). ACE insertion/deletion (I/D) polymorphism vs. Different ACE genotypes (e.g., DD vs I-carriers) was evaluated on Association with obesity, hypertension, insulin resistance, and metabolic syndrome. ACE insertion/deletion polymorphism was not significantly associated with obesity, hypertension, insulin resistance, or metabolic syndrome in Egyptian females.
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