Key result
ACE gene DD genotype is linked to nearly 10-fold higher hypertension risk in obese children.
Why the study?
The role of ACE gene polymorphism in the development of obesity and hypertension in children has not been widely studied.
Is the ACE gene I/D polymorphism associated with obesity and hypertension in Egyptian children and adolescents?
Case-Control (n=142)
Is the ACE gene I/D polymorphism associated with obesity and hypertension in Egyptian children and adolescents?
Absolute Event Rate: 30% vs 11.1%
p-value: p=0.01
The DD genotype and D-allele of the ACE gene polymorphism are associated with obesity and hypertension in Egyptian children and adolescents.
Should not yet change practice; leaves open whether ACE genotyping aids hypertension risk stratification in obese Egyptian youth.
Background: /aims: The role of angiotensin-converting enzyme (ACE) gene polymorphism in the development of obesity and hypertension in children has not been widely studied. We aimed to screen Egyptian obese children and adolescents for insertion/deletion (I/D) polymorphism in the ACE gene. Methods One hundred forty-two children and adolescents were included (70 with simple obesity and 72 controls). Blood pressure was measured, and anthropometric parameters were assessed in all included children and adolescents. Fasting lipid profile, fasting glucose, and insulin were measured. DNA extraction and ACE I/D polymorphism genotyping were also performed. Results Obese children had a higher frequency of DD genotype (30% in obese versus 11.1% in controls, P = .01) and D alleles (61.8% in obese versus 48.6% in controls, P = .01). Obese children with hypertension and prehypertension had higher frequency of DD genotype than II genotype and higher D alleles than I alleles. DD genotype and D allele were independently associated with hypertension (OR: 9.86 and 11.57, respectively, P < .001), while dyslipidemia and insulin resistance were not associated with the ACE I/D gene polymorphism. Conclusion DD genotype and D-allele of the ACE gene polymorphism were associated with obesity and with hypertension and pre-hypertension in Egyptian children.
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El-Kabbany et al. (2019) conducted a case-control in Obesity and hypertension (n=142). ACE gene insertion/deletion (I/D) polymorphism vs. Controls (non-obese) was evaluated on Obesity (DD genotype frequency) (p=0.01). The ACE gene DD genotype was more frequent in obese Egyptian children than controls (30% vs 11.1%, P=0.01) and was independently associated with hypertension (OR 9.86, P<0.001).
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