Key result
ACE genotype II is linked to lower obesity risk in young adult females versus DD/DI.
Why the study?
Obesity is common among young people and ACE plays a role in adipocyte differentiation and fat loading, but its association with obesity in young adults in Jordan was unknown.
Is the ACE insertion/deletion polymorphism associated with obesity among young adults?
Cross-Sectional (n=583)
Is the ACE insertion/deletion polymorphism associated with obesity among young adults?
p-value: p=<0.05
The ACE insertion/deletion polymorphism may be associated with obesity and BMI specifically among young adult females in Jordan.
ACE II genotype may be linked to lower obesity risk in young females; leaves open causal inference and broader validation.
Background: Obesity is very common among the population, including young people. Angiotensin-converting enzyme (ACE) plays a role in differentiation and fat loading in adipocytes. In this study, the association between the ACE insertion/deletion (I/D) polymorphism and obesity among young adults in Jordan was investigated. Methods: The study included 583 young adults (age range: 18–45 years) of both genders. Study participants were categorized into two groups, obese or nonobese, based on body mass index (BMI). The ACE polymorphism was genotyped using the polymerase chain reaction technique. Results: The D allele is common among Jordanians with a frequency of 60.7%. The results found an association between ACE (I/D) and obesity among female participants ( P < 0.05). Females with genotype II were significantly less likely to be obese than females with DD/DI genotypes. In support of the genotypic distribution, the results showed a lower BMI in females with genotype II compared to females with genotypes ID or DD. However, no significant association was found between ACE (I/D) and obesity or BMI among male participants. Finally, no effect of the ACE (I/D) genotypes on the lipid profile was detected. Conclusion: ACE (I/D) may be associated with obesity and BMI among young adult females in Jordan.
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A 2025 study conducted a cross-sectional in Obesity (n=583). ACE insertion/deletion (I/D) polymorphism vs. Genotype II vs DD/DI was evaluated on Obesity (p=<0.05). The ACE insertion/deletion polymorphism was associated with obesity in young adult females, with genotype II being significantly less likely to be obese than DD/DI genotypes (P<0.05).
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