Key result
ACE DD genotype links to higher overweight and obesity risk overall and in Africans.
Why the study?
Is the angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism associated with the risk of overweight/obesity?
Meta-Analysis (n=7,861)
Is the angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism associated with the risk of overweight/obesity?
p-value: p=0.014
The ACE DD genotype is associated with an increased risk of overweight and obesity, particularly in African populations.
ACE DD genotype may elevate obesity risk especially in Africans; leaves open its value for genetic risk stratification.
BACKGROUND AND OBJECTIVE: The association between angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism and the risk of overweight/obesity remains controversial. A meta-analysis was conducted to evaluate the association between ACE I/D gene polymorphism and overweight/obesity susceptibility. METHOD: All eligible studies were included in this meta-analysis by searching PubMed, Embase and Cochrane databases through April 2013 according to a predefined criteria. RESULTS: Fourteen case-control studies including 3371 cases and 4490 controls were recruited for the analysis of the association between ACE I/D gene polymorphism and overweight/obesity susceptibility. A significant association was observed between DD genotype and overweight/obesity risk in overall populations and Africans (p=0.014 and 0.010, respectively). D allele was associated with the risk of overweight/ obesity in Africans (p=0.026). However, II genotype might not be a protective factor against overweight/obesity risk in overall populations, Africans, Caucasians and Asians. CONCLUSIONS: DD genotype is a risk factor for the overweight/obesity susceptibility in overall populations, particularly in Africans. D allele is a risk factor for the overweight/obesity susceptibility in Africans. Further larger studies are needed to confirm our findings.
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Mao et al. (2013) conducted a meta-analysis in Overweight/obesity (n=7,861). Angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism vs. Other genotypes was evaluated on Overweight/obesity susceptibility (p=0.014). The ACE DD genotype was significantly associated with an increased risk of overweight/obesity in overall populations (p=0.014) and in Africans (p=0.010).
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