Why the study?
The association between ACE gene polymorphisms and obesity has been widely studied, but findings remain inconsistent.
Is the ACE gene D/D genotype associated with increased BMI and obesity risk compared to D/I and I/I genotypes?
Meta-Analysis
Is the ACE gene D/D genotype associated with increased BMI and obesity risk compared to D/I and I/I genotypes?
Mean Difference: 0.3 (95% CI 0.07–0.52)
The ACE gene D/D genotype and D allele are significantly associated with elevated BMI and obesity risk.
ACE D/D genotype was associated with modestly higher BMI; supports further genetic-obesity research but should not yet change clinical practice.
Background The association between angiotensin-converting enzyme (ACE) gene polymorphisms and obesity has been widely studied, yet findings remain inconsistent. This study aimed to clarify the relationship between ACE gene insertion–deletion (I/D) polymorphism and obesity. Methods A systematic search was conducted in PubMed, Embase, Scopus, and Web of Science databases without any restriction on publication year up to December 2024. English-language observational studies (cross-sectional, case–control, or cohort) that evaluated the relationship between obesity risk and ACE I/D gene polymorphism were included. Only English-language observational studies (cross-sectional, case–control, and cohort) that evaluated the association between ACE gene I/D polymorphism and obesity risk were selected. Results A total of 46 eligible studies were included. Significant differences in mean body mass index (BMI) were observed across genotypes. Individuals with the D/D genotype had a higher mean BMI compared to those with the D/I (MD = 0.23, 95% CI: 0.03–0.44) and I/I (MD = 0.30, 95% CI: 0.07–0.52) genotypes, indicating a strong association between specific ACE genotypes and BMI variation. Conclusion The D/D genotype and D allele appear to be risk factors for elevated BMI and obesity.
No takes yet. Share an insight, caveat, or question.
Heidari‐Beni et al. (2025) conducted a meta-analysis in Obesity. ACE gene D/D genotype vs. D/I and I/I genotypes was evaluated on Mean body mass index (BMI) (MD 0.30, 95% CI 0.07-0.52).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: