Constriction of Pial Arterioles Produced by Prostaglandin F 2α
Population
Pial arterioles (in vivo model, locally applied to cerebral surface)
Comparison
Prostaglandin F2alpha, alone or in combination… vs Norepinephrine or serotonin alone
Design
Preclinical
Authors
Discussion
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Implication
May implicate prostaglandin F2alpha in cerebral vasospasm; hypothesis-generating for human mechanisms and requires clinical validation.
Structured PICO
P
Population
Pial arterioles (in vivo model, locally applied to cerebral surface)
I
Intervention
Prostaglandin F2alpha, alone or in combination with norepinephrine or serotonin
C
Comparator
Norepinephrine or serotonin alone
O
Outcome
Constriction of pial arteriolessurrogate
Prostaglandin F2alpha produces additive vasoconstriction of pial arterioles when combined with norepinephrine or serotonin, suggesting a potential combined role in pathological vasospasm.
Limitations
- Unclear if experimental doses match concentrations during disease states
- Unclear if vessels become hypersensitive to F2alpha during disease states
Cite This Study
William I. Rosenblum (1975) studied this question.