Why the study?
Does the development of decompensated mitral valve regurgitation alter RAAS activity and NT-proANP concentration in dogs?
Population
11 Cavalier King Charles Spaniels with advanced mitral valve regurgitation attributable to chronic valvular…
Comparison
Observation of natural progression to… vs Data obtained 1 year and 1 to 6 months before…
Design
Preclinical
Follow-up
Until signs of decompensation developed
Authors
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May indicate non-RAAS fluid retention in decompensated canine MR; hypothesis-generating and leaves open RAAS dynamics for further study.
Does the development of decompensated mitral valve regurgitation alter RAAS activity and NT-proANP concentration in dogs?
In dogs with advanced MR, early decompensation is associated with increased NT-proANP but reduced circulating RAAS activity, suggesting fluid retention without systemic RAAS activation.
Häggström et al. (1997) studied this question.
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