Why the study?
Does endothelin administration induce ventricular arrhythmias in anesthetized rats?
Does endothelin administration induce ventricular arrhythmias in anesthetized rats?
Endothelin exhibits a direct arrhythmogenic action in rats that is not solely attributable to myocardial ischemia.
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Endothelin may directly provoke ventricular arrhythmias in rats independent of ischemia; hypothesis-generating for human arrhythmogenesis with no practice implications.
Yorikane et al. (1990) studied this question.
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