Why the study?
Whether the association of leukocyte telomere length with cardiovascular dysfunction differs between measured and genetically predicted telomere length, and its underlying molecular processes, remains unclear.
Does leukocyte telomere length (measured, genetically predicted, and their difference) associate with vascular phenotypes in a general population?
Does leukocyte telomere length (measured, genetically predicted, and their difference) associate with vascular phenotypes in a general population?
Non-genetic causes of leukocyte telomere length contribute to microvascular and cardiac function, potentially mediated through vascular endothelial signaling pathways.
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Measured LTL links to better microvascular function; extends genetic signals but leaves non-genetic contributions hypothesis-generating.
Liu et al. (2023) studied this question.
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