Why the study?
Does a single oral dose of encainide affect hemodynamics in patients with severe chronic heart failure and LVEF <40%?
Population
30 patients with severe chronic heart failure and a left ventricular ejection fraction less than 40%.
Design
Cohort, Unblinded
Follow-up
3 hours
Authors
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Encainide was associated with acute hemodynamic worsening in severe HF; hypothesis-generating and should not yet change practice.
Does a single oral dose of encainide affect hemodynamics in patients with severe chronic heart failure and LVEF <40%?
A single dose of encainide causes significant hemodynamic deterioration and worsening symptoms in patients with severe chronic heart failure.
Gottlieb et al. (1989) studied this question.
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