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October 15, 2001Journal of Virology

Interaction of Classical Swine Fever Virus with Membrane-Associated Heparan Sulfate: Role for Virus Replication In Vivo and Virulence

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Population

Pigs, cultured swine kidney cells (SK6 cells), and primary swine kidney cells

Design

Preclinical

Authors

MHMarcel HulstWageningen University & ResearchRGRené G. P. van GennipDepartment of VirologyAVA. Corina VlotHelmholtz Zentrum München

Discussion

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Implication

In vivo CSFV data support HS-dependent entry without virulence change; hypothesis-generating for pestivirus receptor biology.

Structured PICO

P
Population
Pigs, cultured swine kidney cells (SK6 cells), and primary swine kidney cells
I
Intervention
Infection with HS-independent recombinant virus (S-ST virus) and HS-dependent recombinant virus (S-RT virus)
O
Outcome
Virulence and mechanism of cell infection (HS-dependent vs independent)

In vivo-generated classical swine fever virus can infect cells via a heparan sulfate-dependent mechanism, though alternative receptors are also involved.

Cite This Study

Hulst et al. (2001) studied this question.

synapsesocial.com/papers/6a9276cf915bce628c4f314bhttps://doi.org/10.1128/jvi.75.20.9585-9595.2001
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Also Consider

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  1. 1Tissue culture adaptation of foot-and-mouth disease virus selects viruses that bind to heparin and are attenuated in cattle1997 · 301 citations
  2. 2Changes in disaccharide composition of heparan sulphate fractions with increasing degrees of sulphation1983 · 17 citations
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  4. 4Immunoaffinity purification and characterization of the envelope protein E1 of hog cholera virus1990 · 67 citations